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Introduction: Covaxin and Covishield vaccines have been rapidly rolled out in India to curb the Coronavirus disease-19 (COVID-19) pandemic. The present study tested the effectiveness of COVID-19 vaccination in adults in North India. Effectiveness was tested by considering disease transmission and post-COVID outcomes in infected individuals. Materials and Methods: This study was conducted in the Department of Physiology at MGM College, Jaipur (Rajasthan, India), after approval from the Ethics Committee. Vaccinated and nonvaccinated groups were compared for disease transmission, hospitalization, and clinical outcomes. Researchers collected data using questionnaires circulated through Google forms. The association between attributes was tested using the Chi-squared test. The significance level was considered at 5%. Results: Vaccination significantly reduced disease transmission of COVID-19 (χ 2 = 4.51;P = 0.034). However, no significant differences were seen in the Reverse transcription polymerase chain reaction positivity, chest computed tomography findings, and hospitalization. Similarly, COVID-related symptoms and their severity did not differ significantly between the two groups. The proportion of vaccinated individuals increases with age (χ 2 = 41.68;P < 0.001). Youths and older adults were vaccinated once and twice, respectively (χ 2 = 41.77;P < 0.001). The severity of adverse effects postimmunization (AEFI) was similar in all age groups (χ 2 = 13.22;P < 0.21). Males and females were equally vaccinated (χ 2 = 1.13;P < 0.288). However, males took two doses compared to females (χ 2 = 6,57;P < 0.01). Adverse effects postimmunization were more severe in females than males (χ 2 = 13.10;P < 0.001). Researchers found no association between the number of vaccine doses and the severity of AEFIs (χ 2 = 16.42;P = 0.06). Conclusion: The present study concludes the beneficial effect of vaccination in reducing disease transmission. However, vaccination showed no effectiveness in mitigating other COVID-related outcomes. The following core competencies are addressed in this article: Medical knowledge, systems-based practice, practice-based learning, and improvement. © 2023 International Journal of Academic Medicine ;Published by Wolters Kluwer - Medknow.
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Background: Literature describing triggers of GFAP astrocytopathy (GFAP-A) is limited. We report a case of GFAP-A in a patient with recent messenger ribonucleic acid (mRNA) severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) vaccination and discuss the possible pathogenesis. Case description: A 45-year-old gentleman presented with features of meningoencephalitis 31 days after the first dose and 4 days after the second dose of mRNA SARS-CoV-2 vaccination. He sequentially developed brainstem/cerebellar, autonomic and cord dysfunction. Cerebrospinal fluid was positive for GFAP autoantibody. Clinical improvement occurred after intravenous methylprednisolone and immunoglobulins. Conclusion(s): Although we are uncertain of a causal link of GFAP-A to mRNA vaccine, indirect activation of an underlying dysregulated immune milieu is plausible.Copyright © 2021 The Author(s)
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Background: ChAdOx1-S (vaccine A) and BBV152 (vaccine B) vaccines are currently at the forefront of India's fight against the pandemic. The present study tests the hypothesis that both vaccines are equally efficacious. Material(s) and Method(s): This cross-sectional study was conducted at MGM Hospital, Jaipur (Rajasthan, India). The study compared vaccine A and B recipients on post-vaccination events and COVID-19 related outcomes. Researchers collected data using questionnaires circulated through Google Forms. The association between attributes was tested using the chi-squared test. The significance level was considered at 5%. Result(s): The vaccines A and B recipients were age and gender-matched [p > 0.05]. The vaccines did not differ significantly in vaccine events and adverse events after immunization (p > 0.05). A comparison of COVID-19 related outcomes between the two vaccines revealed no significant differences (p > 0.05). However, the severity of symptoms was higher in vaccine B recipients than in vaccine A recipients [p = 0.027] . Conclusion(s): The present study concludes that vaccines A and B were similar in efficacy. The most crucial factor revealed by the survey is that the reporting of adverse events was significantly less, and awareness is needed. Copyright © 2022 Wolters Kluwer Medknow Publications. All rights reserved.
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PurposePersistent critical issues in built environment higher education (BEHE) curricula may need to be addressed by improving course organisation and management. In addition to the implications of the COVID pandemic, issues such as inadequate communication and lack of contemporary and innovative practices integrated with course delivery have resulted in a gap for Course organisation and management. The purpose of this study is to recommend a set of drivers that can assist academics and academic institutions in improving course development, organisation and management in the BEHE context. Thus, the study focused on three themes: course organisation and administration, timetabling and course communication. Design/methodology/approachA systematic approach was taken to obtain data, where a documental analysis and a close-ended questionnaire were adopted as data collection instruments. The documental analysis considered 334 mid module reviews (MMRs) generating data from architecture, construction management, civil engineering, surveying and real estate students. Content analysis was used to identify critical themes within the MMRs and develop a closed-ended questionnaire. Twenty academics from each discipline completed the questionnaire. Eight drivers were developed from the data obtained from both MMRs and questionnaires. Content analysis and interpretive structural modelling were applied to identify the relationship between the drivers. Finally, these drivers were categorised by their level of influence and reliance to highlight how they contributed to improving course organisation and management. FindingsThe study revealed eight drivers that can improve course organisation and management in the BEHE context. The study found that using virtual learning environments and communication are fundamental in course organisation and management. Practical implicationsThis research paper suggests drivers to improve how academics and academic institutions organise and manage courses. The study recommends eight drivers that could be used as a guideline and a best practice as per the level partitioning diagram developed to enhance the course organisation and management in BEHE. Originality/valueThe study proposes a set of drivers to improve course organisation and management in BEHE curricula. Furthermore, insight into how these drivers influence and rely on each driver and their relation with the national student survey theme are novel contributions to the current body of knowledge. The paper further clarifies how they should be implemented for successful course organisation and management, thus, improving the quality of courses in higher education curricula.
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The evolution of wearable cameras has revolutionized the exponential growth of the industry due to the production of video content. This has ultimately generated the need for storage management, video management, video summarization, methods to reduce the cost of resources, etc. The present paper compares and evaluates the different techniques available for video summarization nowadays and to visualize the need of applying these methods to the content of online classes delivered during the COVID-19 pandemic. This pandemic has affected the lives of children as they all have got stuck totally onto the screen for their education and learning through their respective organizations. But this trend has raised many challenges among the parents, educational lists, and health experts. These challenges mainly include the availability of online gadgets with internet connectivity, especially in rural areas, and the health issues generated because of the overexposure to online gadgets by students all over the world. As per the educational experts, including UNESCO and UNICEF, this continuous exposure to online gadgets has alarmed the different potential dangers to their health including obesity, stubbornness, heart diseases, vision loss, etc. This paper mainly focuses on the need for summarizing the online class videos not only to reduce the burden of the overhead cost of Internet and resources, but also to reduce the harmful effects produced on the health of these students due to the continuous exposure of the unnatural light and waves generated through these gadgets. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Study question Does adding gonadotropin-releasing hormone agonist (GnRHa) to hCG trigger increases the number of high-grade embryos in GnRH antagonist protocol in fresh non-donor IVF? Summary answer Final oocyte maturation triggered by dual trigger increases the number of MII oocytes thus transferring good-quality embryos and cryopreserving surplus embryos compared to hCG trigger. What is known already hCG has been conventionally used as a ‘faux’ LH surge to bring about final oocyte maturation due to structural similarity between the two. GnRH agonist, on the other hand, induces a more physiological gonadotropin surge for follicular maturation, but is associated with luteal phase deficiency. Recent studies have shown that combining GnRHa with hCG trigger improves oocyte maturation and embryo quality with the added benefit of a luteal phase support, thereby improving IVF outcomes in terms of both embryological and reproductive outcomes. Study design, size, duration A single-center, open labelled, randomized controlled trial including 100 normal responder patients between 21-38 years undergoing IVF using GnRH antagonist protocol between January 2020 to August 2021. The study excluded patients with the presence of other variables of adverse outcomes like diminished ovarian reserve (AFC < 5 or AMH < 1.2 ng/ml), endocrine disorders, thin endometrium (<6mm), previous history of uterine surgeries, and high responders. Participants/materials, setting, methods 100 patients undergoing fresh IVF cycle using GnRH antagonist protocol were randomized after informed consent to receive either dual trigger (Leuprolide acetate 1 mg + rhCG 250 mcg, n = 50) or single hCG trigger (rhCG 250 mcg, n = 50). Oocyte retrieval was done 35-37 hours after trigger followed by IVF/ICSI, as indicated. Oocyte and embryo grading was done using Istanbul consensus. Analysis was done by ITT. Outcomes were analyzed using Independent t-test and Chi-square test. Main results and the role of chance The baseline characteristics were comparable in both arms. the number of MII oocytes retrieved (7.82 versus 5.92, p = 0.003) and the number of day-3 grade-1 embryos (4.24 versus 1.8, p < 0.001) were higher in the dual trigger group, whereas fertilization rates between the two groups (91.82% versus 88.51%, p=NS) were comparable. Consequently, the number of embryos cryopreserved (2.68 versus 0.94, p < 0.001) were significantly higher in the dual trigger group. However, the implantation rate between the two groups (21% versus 19.6%, p = 0.770) was comparable. The serum LH levels 12 hours post trigger were measured in both the arms and as expected, high serum LH values were documented in the dual trigger group (46.23 mIU/ml vs 0.93 mIU/ml, p < 0.0001). Limitations, reasons for caution Due to the impact of the Covid-19 pandemic causing an intermittent pause in IVF services at our center, a smaller sample size of 100 patients could be enrolled in the study, and reproductive outcomes in terms of live births and cumulative live births could not be assessed Wider implications of the findings This study, though small, has contributed to some evidence of redesigning the dual trigger in all antagonist cycles, with the exception of high responders and PCOS patients. The addition of GnRHa to hCG trigger has led to the possibility of cryopreserving surplus embryos thereby increasing the cumulative live births. Trial registration number CTRI/2020/08/027030
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The study aims to analyze the change in coverage of health issues awareness, printed on the front page of Indian e-papers (The Hindustan Times and The Times of India) for the pre- and peri-coronavirus period. The collected news articles are examined by performing the latent dirichlet allocation algorithm. The sentiment analysis is performed to analyze the change in the emotions aroused from news articles. The outcome regarding the pre-coronavirus period reveals that the focus of the e-papers was mostly on politics, crime, and economy whereas, in the peri-coronavirus period, the e-papers are focusing more (i.e. 40% topics) on publishing the news related to disseminating the awareness about the coronavirus disease. The priority of news topics includes the active number of cases, medical facilities, and COVID-19 testing. The outcome regarding sentiment analysis reveals that negative sentiments are prominent in the peri-coronavirus period due to fear of the outbreak of the virus.
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Objective: To describe the spectrum of acute neurological disorders among hospitalized patients who recently received COVID-19 mRNA vaccination. Background: The unprecedented pace of COVID-19 vaccine development, use of novel mRNA technology and large-scale vaccination programs have engendered concerns of adverse events following immunization. Design/Methods: We performed a multi-centre prospective observational study in 7 public acute hospitals. Hospitalized patients who were referred for neurological complaints and had COVID-19 mRNA vaccines, BNT162b2 and mRNA-1273, in the last 6 weeks were classified into central nervous system(CNS) syndromes, cerebrovascular disorders, peripheral nervous system(PNS) disorders, autonomic nervous system(ANS) disorders and immunization stressrelated responses(ISRR). To contextualize our findings, data from National Immunization Registry was probed for the total number and demographic of individuals vaccinated in the corresponding period. Results: From 30 December 2020 to 20 April 2021, 1,398,074 persons (median age 59 years, 54.5% males) received COVID-19 mRNA vaccine (86.7% BNT162b2, 13.3% mRNA-1273);915,344 (65.5%) completed 2 doses. Four hundred and fifty-seven (0.03%) patients were referred for neurological complaints [median age 67 years, 61.5% males;95.8% received BNT162b2 and 4.2% mRNA-1273];classified into 73 (16.0%) CNS syndromes, 286 (62.6%) cerebrovascular disorders, 59 (12.9%) PNS disorders, 0 ANS disorders and 39 (8.5%) ISRRs. Twenty-seven had cranial mononeuropathy, 11 of whom had Bell's palsy. Of 33 patients with seizures, only 4 were unprovoked and occurred within 2 weeks of vaccination. All strokes occurred among individuals with pre-existing cardiovascular risk factors. We recorded 2 cases of cerebral venous thrombosis;none associated with thrombocytopenia. Five had mild flares of immune-mediated diseases. Conclusions: Our observational study does not establish causality of the described disorders to vaccines and is limited by lack of baseline incidence data of several conditions. Nevertheless, we did not observe any obvious signal of serious neurological morbidity associated with mRNA vaccination. The benefits of COVID-19 vaccination outweigh concerns over neurological adverse events.
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Purpose The issues in the current Built Environment Higher Education (BEHE) curricula recognise a critical need for enhancing the quality of teaching. This paper aims to identify the need for a best practice in teaching within BEHE curricula and recommend a set of drivers to enhance the current teaching practices in the Built Environment (BE) education. The study focused on Section 1 of the National Student Survey (NSS) - Teaching on my course, with a core focus on improving student satisfaction, making the subject interesting, creating an intellectually stimulating environment and challenging learners. Design/methodology/approach The research method used in this study is the mixed method, a document analysis consisting of feedback from undergraduate students and a closed-ended questionnaire to the academics in the BEHE context. More than 375 student feedback were analysed to understand the teaching practices in BE and fed forward to developing the closed-ended questionnaire for 23 academics, including a Head of School, a Principal Lecturer, Subject Leads and Lecturers. The data was collected from Architecture, Construction Management, Civil Engineering, Quantity Surveying and Building surveying disciplines representing BE context. The data obtained from both instruments were analysed with content analysis to develop 24 drivers to enhance the quality of teaching. These drivers were then modelled using the interpretive structural modelling (ISM) method to identify their correlation and criticality to NSS Section 1 themes. Findings The study revealed 10 independent, 11 dependent and three autonomous drivers, facilitating the best teaching practices in BEHE. The study further recommends that the drivers be implemented as illustrated in the level partitioning diagrams under each NSS Section 1 to enhance the quality of teaching in BEHE. Practical implications The recommended set of drivers and the level partitioning can be set as a guideline for academics and other academic institutions to enhance the quality of teaching. This could be further used to improve student satisfaction and overall NSS results to increase the rankings of academic institutions. Originality/value New knowledge can be recognised with the ISM analysis and level partitioning diagrams of the recommended drivers to assist academics and academic institutions in developing the quality of teaching.
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As the coronavirus (COVID-19) grows its impact from China, expanding its catchment into surrounding regions and other countries, increased national and international measures are being taken to contain the outbreak. This perspective paper is written to capture and analyze the various mental state health issues being perceived via emotional analysis of Twitter data during the COVID-19 virus outbreak from a single nation further spread of to the whole world. A data-driven approach with higher accuracy as here can be very useful for a proactive response from the government and citizens. In the proposed work, tweets during the COVID situation have been collected and their sentiments are explored using BERT (Bidirectional Encoder Representation from Transformer) algorithm. BERT is the algorithm that takes text as input, and the trained basis on the epochs (number of passes performed). The performance parameters are computed such as accuracy, precision, recall, and F-measure. Further, the proposed approach is compared with other existing algorithms such as Naïve Bayes (NB), support vector machine (SVM), and logistic regression (LR). The performance measures indicate that the BERT algorithm outperforms all other existing algorithms with an accuracy of 86.7% as compared to 67.3%, 63.4%, and 61.2% with Naïve Bayes, support vector machine, and logistic regression, respectively. The government and other medical health agencies can use the outcomes of this paper for implementing and taking preventative measures to maintain the good mental and physical health of medical staff. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Mental health issues are very prominent in the modern world. Almost one in four people in the world are suffering from mental illness. The world has been going through a major pandemic known as a coronavirus which was first reported in China. People are at risk of getting mentally ill due to various restrictions imposed such as lockdown and social distancing. Our study aims to analyze the mental suffering of the people toward the outbreak. The analysis is done using tweets from ten different countries. For analyzing, artificial intelligence is used under which the sentiment analysis is performed illustrating fear is the most prominent emotion prevailing in the people followed by other negative emotions like sadness, anxiety, disgust, and anger. The correlation analysis indicates that negative emotion like fear is highly correlated with other negative emotions. It pinpoints the fact that the spreading of coronavirus has widely affected the mental health of the people. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Coronavirus disease-2019 pandemic is presently wreaking havoc on general public health, food systems, human dignity, and labour around the world. The availability and potential delivery of a safe and effective vaccination to communities around the world is being viewed not only as a means of overcoming these obstacles, but also as a demonstration of human resilience in the face of hardship. Nations must mobilise their resources to ensure widespread access to vaccines, without which the true benefits of development will be lost. Despite its vast internal needs, our country is seen with both hope and anticipation for its ability to deliver at this critical moment in human civilization's progress, and India is more than willing to contribute. © The Authors.
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Objective: To describe the neurological disorders associated with COVID-19 in Singapore. Background: Various neurological disorders have been reported in COVID-19 patients. Postulated mechanisms include hypercoagulopathy, dysimmunity, inflammation and direct viral invasion. The incidence and relationship to SARS-CoV-2, considering the confounding effect of a surge in COVID-19 cases on healthcare systems, are unclear. Design/Methods: This was a prospective, nation-wide, multi-centre, cohort study of patients with microbiologically-confirmed COVID-19 referred for any neurological complaints With in 3 months of infection. Neurological diagnoses and relationship to COVID-19 were made by consensus guided by contemporaneous published case definitions. Results: Between March-July 2020, 47,572 patients [median age 34 (1-102) years, 98% males] were diagnosed with COVID-19 in Singapore. Of 90 patients referred for neurological disorders, 39 [median age 41 (27-73) years, 97% males] were deemed related to COVID-19 and categorised as: i) Central nervous system syndromes - 3 encephalitis, 1 acute disseminated encephalomyelitis;ii) Cerebrovascular disorders - 19 acute ischemic stroke/transient ischemic attack (AIS/TIA), 4 cerebral venous thrombosis (CVT) and 2 intracerebral haemorrhage;iii) Peripheral nervous system - 7 mono/polyneuropathy;iv) Autonomic nervous system - 4 limited dysautonomia. Fifty-one other patients had pre/co-existent neurological conditions (headache, seizure, mononeuropathies and functional neurological disorders) unrelated to COVID-19. Encephalitis is delayed, occurring in critical COVID-19, while CVT and dysautonomia occurred relatively early and largely in mild infections. AIS/TIA was variable in onset;remarkably 63.2% had asymptomatic COVID-19. CVT was more frequent than expected and occurred in patients with mild/asymptomatic COVID-19. The pathophysiology of COVID-19 neurology appeared to be dysimmunity and/or prothrombotic tendency. There were no neurological complications in all 81 paediatric COVID-19 cases. Conclusions: COVID-19 neurology has a wide spectrum of dysimmune-thrombotic disorders. The relatively few cases recorded was probably because our outbreak affected mainly healthy young men with mild/asymptomatic COVID-19 and the pandemic did not unduly affect the Singapore healthcare system.
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Purpose This study aims to assess "learning opportunities" provided to undergraduate students, from level three to six, in higher education (HE). A knowledge gap was identified within the current practice relating to learning opportunities for built environment (BE) students in HE. The study focussed on the themes under section two of the national student survey (NSS): how students explore ideas or concepts in-depth, bring information and ideas together from different topics and apply the learned content in a real-life context. The study aimed to provide recommendations for enhancing "learning opportunities" to the BE students within HE. Design/methodology/approach Data collection focussed on section two of NSS "learning opportunities" and documentary analysis, and a qualitative survey were adopted for this study. A documental analysis of 334 mid-module reviews was carried out. The qualitative data was collected from level three to level six students and academics from architecture, construction management, civil engineering and quantity surveying disciplines representing BE context. A sample of 40 students and 15 academics, including a Head of school, a Principal lecturer, Subject leads and lecturers, participated in interviews as part of a qualitative survey. In total, 12 drivers were developed using the data obtained through literature, documental analysis and interviews. These drivers were analysed using manual content analysis to identify their influence on the specified themes under NSS section two and circulated amongst academics to be ranked by identifying its influence to promote learning opportunities to BE students in HE. Findings This study highlighted 12 drivers which promote learning opportunities in HE within BE curriculum. Findings established that topics should be explained with more real-life or industry-orientated concepts such as simplification integrated into module delivery. Contrary to the literature, the use of physical materials (i.e. handouts and whiteboard) in addition to a virtual learning environment for detailed explanations were considered effective in exploring concepts. During the current COVID-19 pandemic, context-based learning needs to be promoted by integrating videos of practical implementation for better understanding. The study recognised that lab, fieldwork and tutorials were essential to apply what students have learned in BE curricula to a real-life context. Originality/value This study identified current learning approaches and provided recommendations to improve the BE students learning experience in HE. They identified 12 drivers that would significantly help academics and academic institutions to understand how learning opportunities should be facilitated in the BE curriculum to enhance student performances in HE.
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Background:COVID 19 outbreak miens critical concern to global education system across the world. The closure of universities has left billions of students behind. Nursing educators and students relied on technology to continue learning online during the pandemic. However, online education is hampered by the lack of networks, power, infrastructure such as inaccessible and lack of digital skills. Aim: The aim of the study was to evaluate the impact of the COVID 19 outbreak on nursing education. Objectives: 1. To assess the perception regarding impact of corona pandemic on nursing education, limitations of E-learning and required modifications among nursing educators. 2. To find out the association between perception of nursing educators with their socio-demographic variables. Material and Methods: Quantitative Cross sectional research design was adopted with Non probability technique(Convenient sampling) .Data were collected through a Google form consisting of self-structured Likert scale on perceptions of nursing educators. The Subdomains of the perception were impact of COVID-19 outbreak on Nursing education, Limitations of e-learning and essential modifications required. Result: of the study revealed that the corona pandemic outbreak has adversely impacted nursing education and urgent need to implement effective e-learning teaching learning strategies of nursing educators to understand their perception and issues they are facing during e-classes to foster teaching-learning.The mean and SD of (7.9 + 3.9) shows negative impact of COVID pandemic on nursing education and are of limitations in E-learning methods with a mean and SD score of (6.2 + 2.4). Conclusion: The process of imparting education has seen a sea change during the threat of the COVID pandemic. Besides, technology is affecting every side of society and changing it regularly. Challenges in the E-learning context shows the requirement for up-gradation in institutional technology infrastructure and teacher’s capacity building training to improve technological expertise.
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A novel threat to mankind by novel coronavirus infection occurred in December 2019. According to the World Health Organization (WHO) Situation Report-141, 7,039,918 confirmed cases and 404,396 death cases were observed till 9 June 2020 in the different regions of world. Therefore, this article aims to summarize and share the update on the present status of the outbreak and possible treatment options. The present review focuses on latest statistics, diagnostic and preventive measures under study and the future planning of the researchers to discover an effective cure for this threat to the mankind. For carrying out this review, literature searches were performed on Clinicaltrials.gov, official website of WHO,Centers for Disease Control and Prevention, PubMed, Google scholars, etc. Data from these searches was collected and evaluated for getting the available literature on COVID-19 outbreak and drugs under study. The details of history, virology, epidemiology, possible therapeutic options, associated risk factors and preventive measures related to COVID-19 are compiled here in this review. Along with this, some ongoing clinical trials have also been included in this review in order to conclude the efforts of researchers towards controlling this outbreak. The trajectory and severity of this outbreak can't be predicted at present, but immediate actions are required to be taken in order to develop and implement an effective treatment against the global threat. © 2020 This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC-BY). Published by Oriental Scientific Publishing Company.
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Background: Canadian provinces initiated states of emergency (SoE) between March 13 and March 23 2020 due to community transmission of COVID-19 We explore changes in self-reported quality of life (QoL) in patients with PBC early-on during SoE Methods: Patients with PBC from the Canadian Network for Autoimmune Liver disease who completed QoL questionnaires between July 2019 and June 2020 are included Questionnaires include the Short-Form 36 (SF-36), PBC-40, and Itch Numeric Rating Scale (iNRS) Measurements during SoE are after March 17 2020, date of SoE initiation in Ontario Measurements before Feb 1 2020 are pre-SoE Measurements between Feb 1 and March 16 2020 are excluded given growing societal concern during this time, but no formal SoE Analyses include mixed effects regressions of QoL scores with SoE as a binary variable Models are adjusted for duration of disease and age at diagnosis and employ random intercepts at clinic and patient level Results: 312 patients were included from Toronto (64%, n=198), Montreal (14%, n=43), Edmonton (7 7%, n=24), Ottawa (5 8%, n=18), Saskatoon (5 4%, n=17), and Kingston (3 8%, n=12) The majority of patients were female (93%, n=291), Caucasian (82%, n=256), and born in Canada (78%, n=242) Mean age was 58 6 years (SD 10 8), mean age at diagnosis was 49 3 years (SD 11 0), mean duration of disease was 9 0 years (SD 7 2), and 6 4% (n=20) had overlap with autoimmune hepatitis Patients had a mean of 1 3 (SD 0 5) repeated measures (maximum 3) 219 patients had measures pre-SoE and 128 had measurements during SoE Estimated mean SF-36 physical component scores were similar before and during the first 3 months of SoE (41.9 vs 40.7, p=0.16), as were SF-36 mental component scores (43 3 vs 43 5, p=0 91) When compared to average Canadian population SF-36 scores, patients with PBC had significantly worse scores before and during SoE (p<0 001 all comparisons) PBC-40 domain scores remained stable, with estimated mean values before and during SoE as follows: Symptoms 13 8 vs 14 2 (p=0 32), Fatigue 24 9 vs 25 0 (p=0 81), Cognitive 10 8 vs 11 1 (p=0 47), Socio-Emotional 25 4 vs 26 2 (p=0 20), Itch 4 7 vs 4.9 (p=0.44). There was a small but statistically significant increase in estimated mean iNRS score, from 2 4 pre-SoE to 3.3 during the first 3 months of SoE (p<0.001). Conclusion: Quality of life scores remained largely stable during the first three months of Canada's SoE SF-36 scores in patients with PBC were significantly worse than Canada's general population Analyses should be updated as Canada's SoE continues.